The Griffs (6-7) are making their second trip to the NCAA Tournament after earning the program's second conference title on Sunday. Canisius defeated second-seeded Detroit, 12-10, in the semifinal before earning a 10-9 victory against top-seeded Siena to win the title.
In its only other appearance in the NCAA Tournament, Canisius fell to eventual national champion Syracuse in 2008.
Loyola enters the NCAA Tournament with a 14-1 record and won the ECAC Championship on Friday over Fairfield, 14-7. The Griffs and Greyhounds have never met previously in men's lacrosse.
Tickets for the game will be available at 11 a.m. on Monday by visiting LoyolaGreyhounds.com or calling (410) 617-1420. The game can also be seen live on ESPNU and ESPN3.